One of the big, overarching jokes of 22 Jump Street was the fact that it kept constantly pointing out the fact that it was a sequel that more or less trod the same ground of the original but with a bigger budget. It even went so far as to point out certain things about the non-existed third movie, writing it off as a ridiculous notion and lampooning the over-extended future of the franchise with a massive array of fictional sequel posters that flashed over the credits. Observe.
“We’ve found a way that we love that makes those imagined sequels canonical and yet does something that we haven’t told you about yet. The sequels are canon.”
This is seemingly in line with earlier suggestions that they might be leaning in that direction; to embrace all those ridiculous and magnificent sequels and drop the story of 23 Jump Street into a world where, somehow, they’ve all already taken place.